Table 2 Inclusion and exclusion criteria
| Inclusion criteria | Exclusion criteria |
|---|---|
|
▪ Adults 18 to 40 years of age ▪ Confirmed diagnosis of POTS [1] and currently attending specialist out-patient clinics ▪ Able to attend a PULSE centre 1–2 times/week for 8–12 weeks for exercise training ▪ Able to provide informed consent |
▪ Absolute contraindications to exercise as per international clinical guidelines [11, 12] ▪ Any serious mental health/cognitive issue that will prevent engagement with study procedures or increase the risk of exercise complications ▪ Unable to make suitable travel arrangements ▪ Currently undertaking structured exercise/physical activity equivalent to the Chief Medical Officer (CMO) guidelines (150 min moderate exercise per week or 60 min vigorous per week) ▪ Previous randomisation in the present trial ▪ Pregnancy ▪ Taken part in co-creation workshops to design the PULSE intervention/study |